Other Definitions
synovial fluid (dict)
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Synovial FluidSynovial fluid is a thick, stringy fluid found in the cavities of synovial joints. With its egg-like consistency (synovial comes from Latin for "egg") synovial fluid reduces friction between the articular cartilage in joints to lubricate and cushion them during movement. Overview The inner membrane of synovial joints is called the synovial membrane, which secretes synovial fluid into the joint cavity. This fluid forms a thin layer (approximately 50 micrometres) at the surface of cartilage, but also seeps into the articular cartilage filling any empty space http://www.ucl.ac.uk/~regfjxe/NORMALJOINT.htm. The fluid within articular cartilage effectively serves as a synovial fluid reserve. During normal movements, the synovial fluid held within the cartilage is squeezed out mechanically (so-called weeping lubrication) to maintain a layer of fluid on the cartilage surface. Anatomy Normal synovial fluid contains 3-4 mg/ml hyaluronan (hyaluronic acid), a polymer of disaccharides composed of D-glucuronic acid and D-N-acetylglucosamine joined by alternating beta-1,4 and beta-1,3 glycosidic bonds http://www.glycoforum.gr.jp/science/hyaluronan/HA01/HA01E.html. Hyaluronan is synthesized by the synovial membrane and secreted into the joint cavity to increase the viscosity and elasticity of articular cartilages and lubricate the surfaces between synovium and cartilage http://www.orthop.washington.edu/arthritis/general/joints/04. Synovial fluid also contains lubricin secreted by synovial cells. It is chiefly responsible for so-called boundary-layer lubrication, which reduces friction between opposing surfaces of cartilage. There is also some evidence that it helps regulate synovial cell growth http://arthritis-research.com/content/5/S3/5. Health and disease Classification Synovial fluid can be classified into normal, noninflammatory, inflammatory, septic, and hemorrhagic: | lassification of synovial fluid in an adult knee joint | | gcolor="#ffffff"| | Normal | Noninflammatory | Inflammatory | Septic | Hemorrhagic | | gcolor="#cccccc"| Volume (ml) | <3.5 | >3.5 | >3.5 | >3.5 | >3.5 | | gcolor="#cccccc"| Viscosity | High | High | Low | Mixed | High | | gcolor="#cccccc"| Clarity | Clear | Clear | Cloudy | Opaque | Mixed | | gcolor="#cccccc"| Color | Colorless/straw | Straw/yellow | Yellow | Mixed | Red | | gcolor="#cccccc"| WBC/mm3 | <200 | 200-2,000 | 2,000-75,000 | >100,000 | Same as blood | | gcolor="#cccccc"| Polys (%) | <25 | <25 | >50 | >75 | Same as blood | | gcolor="#cccccc"| Gram stain | Negative | Negative | Negative | Often positive | Negative | Pathology Many synovial fluid types are associated with specific diagnoses http://www.fpnotebook.com/RHE64.htm http://www.rheumatology.org/publications/primarycare/number6/hrh0033698.asp?aud=mem: - Noninflammatory (Group I)
- Inflammatory (Group II)
- Septic (Group III)
- Hemorrhagic
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