1541

• The first official translation of the entire Bible in Swedish
• February 12 - Pedro de Valdivia founds Santiago de Chile.
• May 8 - Hernando de Soto reaches the Mississippi River naming it Rio de Espiritu Santo.
• May 23 - Jacques Cartier departs Saint-Malo France on his third voyage.
• August 29 - The Janissaries of Suleiman the Magnificent take Buda by ruse, hiding themselves as tourists.
• Muslims seal off The Golden Gate in Jerusalem.
• Irish Parliament declares Ireland to be a kingdom

• March 21 - Francesco I de' Medici, Grand Duke of Tuscany (d. 1587)
• El Greco - Spanish artist (d. 1614)
• Hatano Hideharu - Japanese daimyo and samurai

• May 27 - Margaret Pole, 8th Countess of Salisbury, daughter of George, Duke of Clarence (executed) (b. 1374)
• June 26 - Francisco Pizarro, Spanish conquistador of Peru
• November 24 - Margaret Tudor, widowed Queen consort of King James IV of Scotland.

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